Power House Of A Cell
Loss of a key molecule complex may be the cause of many mitochondrial Dna disorders.
The mitochondria, frequently labeled the powerhouse of the cell, are the organelle responsible for free energy production inside the cell. Playing an important role in cellular respiration, the mitochondria are the main location for ATP production. They also make proteins essential for DNA metabolism such as the fe-sulfur family unit of proteins.
Mitochondria take their own genome, inherited purely from the female parent, which is formed of xvi,569 base of operations pairs. The double stranded, circular molecule contains 37 genes and codes for two rRNAs, 22 tRNAs and 13 polypeptides.
Loss of the mitochondrial DNA has been shown to result in impaired cell metabolism, reduced jail cell function and, eventually, cell expiry. This is due to the cells inability to generate the necessary amount of ATP, which leads to an increase in oxygen free radicals that damage genetic fabric, preventing gene expression.
A recent study from the University of Seville (Espana) has identified a likely origin for the DNA deposition pathway, linking it to the diprotein complex degradasome. The results, published in Proceedings of the National Academy of Sciences, found that degradasome is essential for the maintenance of the integrity of the mitochondrial genome past removing any defective RNA, a process needed for the further propagation of salubrious mitochondria.
Loss of the degradasome complex leads to accumulation of the RNA, forming abnormal hybrid structures that, when in backlog, tin can preclude mitochondrial DNA replication. The activity of these Deoxyribonucleic acid-RNA hybrids means that when cells carve up, they lose the necessary mitochondrial Deoxyribonucleic acid that compromises cellular office.
It is hoped that the results of this study volition help to further understand the molecular mechanisms for some mitochondrial diseases, assisting in the development of novel therapies and treatments.
Power House Of A Cell,
Source: https://www.biotechniques.com/biochemistry/protecting-the-powerhouse/
Posted by: cookgerentow.blogspot.com
0 Response to "Power House Of A Cell"
Post a Comment